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The mixture germline classification for this variant, normally to get a monogenic or Mendelian disorder as during the ACMG/AMP recommendations, or for reaction into a drug. This value is calculated by NCBI dependant on facts from submitters. Read through our guidelines for calculating the mixture classification.

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The publishing Firm for this submitted (SCV) history. This column also contains the SCV accession and Model selection, the day this SCV first appeared in ClinVar, and also the date that this SCV was final updated in ClinVar.

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03%). This variant has not been claimed from the literature in men and women affected with GAA-connected ailments. ClinVar has an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice internet site are a comparatively widespread cause of aberrant splicing (PMID: 17576681, 9536098). Algorithms made to predict the effect of sequence variations on RNA splicing propose this variant may perhaps generate or strengthen a splice web-site. In summary, the obtainable proof is at present inadequate to find out the part of this variant in disorder. As a result, it has been categorised like a Variant of Uncertain Importance. OK

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